Abstract
To the Editor: The plasma renin activity (PRA) test quantifies the circulating activity of the renin-angiotensin system by measuring the rate at which renin forms angiotensin I (Ang I) in plasma. The PRA test overestimates the true activity of the circulating renin-angiotensin system in patients taking angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) because these drugs block the system at sites distal to the enzymatic release of Ang I by plasma renin.1,2 When patients are taking these drugs, a simple calculation can be used to determine …
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