Abstract
The review sets out modern ideas about the mechanisms of action of gamma-aminobutyric acid (GABA) in the central nervous system and other organs and systems. Current experimental and clinical studies have shown that GABA has numerous effects: neuroprotective, antihypertensive, antidiabetic, antitumor, anti-inflammatory, antimicrobial, anti-allergic, hepatoprotective, nephroprotective and enteroprotective, and others, which are currently the subject for study by biologists, physiologists, and physicians. Synthetic GABA analogues are widely used in clinical practice. One of these drugs is aminophenylbutyric acid hydrochloride (Anvifen®) that has demonstrated high efficiency and safety in clinical practice.
Highlights
В обзоре изложены современные представления о механизмах действия гамма-аминомасляной кислоты (ГАМК) в ЦНС и других органах и системах
The review sets out modern ideas about the mechanisms of action of gamma-aminobutyric acid (GABA) in the central nervous system and other organs and systems
Current experimental and clinical studies have shown that GABA has numerous effects: neuroprotective, antihypertensive, antidiabetic, antitumor, anti-inflammatory, antimicrobial, anti-allergic, hepatoprotective, nephroprotective and enteroprotective, and others, which are currently the subject for study by biologists, physiologists, and physicians
Summary
В обзоре изложены современные представления о механизмах действия гамма-аминомасляной кислоты (ГАМК) в ЦНС и других органах и системах. Frankel в The Journal of Biological Chemistry сообщили об обнаружении в тканях головного мозга ГАМК [1]. Клиницисты широко используют ГАМК-ергические препараты, зачастую даже не задумываясь о механизме их действия, при различных заболеваниях и состояниях.
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