Effective method for the development of the liposomal nanoformulations of docetaxel

Abstract

Docetaxel has been regarded as among the most effective chemotherapeutic medications in recent decades, but its low solubility in water with systemic toxicities have made it difficult to use in clinical trials. Nanotechnology has supplied docetaxel with innovative drug delivery technologies in recent decades, allowing it to increase their water solubility and lessen adverse effects. Liposome was successfully used for encapsulation the Docetaxel in variant conditions and optimized to synthesis lecithin liposome and loaded one. The thin film hydration method was demonstrated for nanocapsules. The synthesized Docetaxel-liposome formula was investigated by SEM, TEM and zeta potential used for liposome stability. Encapsulation and loading efficiency was determined and releasing kinetics was studied at pH= 5.5 and 7. The kinetics models were studied included: zero-order, first-order order, Higuchi, and Korsmeyer Peppas model. The docetaxel-liposome was examined for its activity to kill prostate cancer in the cell line method and compared to free docetaxel (pure sample) and pharmaceutical formula. Our formula was very effective against prostate cancer and statistically significance.