Abstract
We examined the suppressive effect of HIV-1 RNA gene cleavge on HIV-1 expression, using the catalytic RNA subunit RNase P and the 3′-half tRNA Try [external guide sequence (EGS)] in cultured cells. HIV-1 expression was inhibited by the tRNA met-EGS-U5 and U6-EGS-U5 from the tRNA met and U6 promoters, respectively. There was no difference in the inhibitory effects on HIV-1 expression between the tRNA met and U6 promoters.
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