Effective factors on Sharp Score in patients with rheumatoid arthritis: a retrospective study

Jianting Wen,Yanqiu Sun,Xin Wang,Hui Jiang,Ling Xin,Yue Sun,Jian Liu,Lei Wan,Jie Wang

doi:10.1186/s12891-021-04742-3

Jianting Wen, Yanqiu Sun + Show 7 more

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https://doi.org/10.1186/s12891-021-04742-3

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Abstract

BackgroundThis study aims to describe the association between sharp score and clinical indexes, bone metabolism indexes, Disease Activity Score (DAS28) and sociodemographic factors in rheumatoid arthritis (RA).MethodsData were collected from the HIS (hospital information system), a national inpatient database in China, with information on the patients hospitalized during the period from 2012 to 2019. The association between sharp score and effective factors were identified using multinomial logistic regression and association rule mining (ARM).ResultsThree thousand eight hundred and forty patients were included: 82.66% males, 17.34% females, mean (SD) age 56.95 (12.68) years and symptom duration 3.45 (1.09) years. Spearman correlation analysis and Association rules analysis showed that there were significant positive correlations between sharp score and effective factors. Logistic regression analysis presented that erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (CRP), rheumatoid factor (RF) were risk factors of sharp score. In the analysis of individual outcomes, sex, age, symptom duration, DSA28 score, RF, ever drinker, and radiographic grading of hands were influence factors of sharp score.ConclusionSharp score should be taken into consideration in formulating treatment strategies in RA.

Highlights

This study aims to describe the association between sharp score and clinical indexes, bone metabolism indexes, Disease Activity Score (DAS28) and sociodemographic factors in rheumatoid arthritis (RA)
The following clinical data were obtained from all participants: age; sex; laboratory data, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (CCP), immunoglobulins A (IGA), immunoglobulin G (IGG), immunoglobulin M (IGM), complement 3 (C3), and complement 4 (C4), bone alkaline phosphatase (BALP), osteocalcin (OC), Osteoprotegerin (OPG), receptor activator for nuclear factor-κB ligand (RANKL); DAS28 score, and sharp score
Spearman correlation analysis of sharp score and clinical indexes To determine whether correlations existed between sharp score and clinical indexes, a Spearman correlation test was performed

Summary

Introduction

This study aims to describe the association between sharp score and clinical indexes, bone metabolism indexes, Disease Activity Score (DAS28) and sociodemographic factors in rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial membrane inflammation [1, 2]. Erosive joint damage and bone destruction are the most common manifestation of RA, which might induce ankylosis, malformation, even loss of normal joint function [3, 4]. Current goals of treatment in RA include achieving disease remission, reducing functional disability as well as minimizing pain [5, 6]. Erosions are the hallmark of bone destruction in RA [7, 8]. This study retrospectively analyzed the clinical data of enrolled patients to investigate the value of sharp score and its effective factors in RA.

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