Abstract
The authors describe a method for monitoring dicyclanil levels in lamb and chicken muscle tissues. The devised procedure involves dicyclanyl extraction by SPE and its detection HPLC-UV/Vis and LC/MS/MS. The method was found to have LOD and LOQ values of <TEX>$0.02\;mg\;kg^{-1}$</TEX> and <TEX>$0.05\sim0.06\;mg\;kg^{-1}$</TEX>, respectively. The intraday precision and an accuracy of spiked samples were found to have 2.3~10.4 RSD% and 80.9~105.7%, respectively.
Highlights
Veterinary drugs are widely used to treat and prevent disease, and are administered to livestock in feed or drinking water.[1,2] the improper use of these drugs can leave residues in tissues, which can lead to health problems for human who consumes the animal products
It is difficult to retain dicyclanil in chromatographic reversed-phase mode, and a chromatographic mode based on the ion pair mode (heptafluorobutyric acid (HFBA)) was used
LC/MS/MS analysis was used to confirm the detection of dicyclanil
Summary
Veterinary drugs are widely used to treat and prevent disease, and are administered to livestock in feed or drinking water.[1,2] the improper use of these drugs can leave residues in tissues, which can lead to health problems for human who consumes the animal products. Dicyclanil (Figure 1) is a pyrimidine-derived insect growth regulator that is used by veterinarians to prevent myiasis or fly-strike,[3,4] but the presence of residual dicyclanil, has received much attention because it has become a consumer safety issue. The Korean Food and Drug Administration had established a maximum residue limit (MRL) of 0.15 mg/kg of dicyclanil in sheep and chicken muscle. The development of simple and rapid methods for the determination of dicyclanil levels in sheep and chicken muscle meat has become increasing important.
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