Effect research of two kinds of airway humidification solution for patients with tracheotomy of airway humidification

Abstract

Objective To compare the influence of tracheotomy after two wet fluid on airway and provide the basis for clinical treatment and care. Methods A total of 30 patients with severe brain injury stay neurosurgery tracheotomy were divided into 0.45% sodium chloride group and ambroxol hydrochloride group with 15 cases each by random digits table method, two airway humidification liquid (0.45% sodium chloride, 0.9% sodium chloride + ambroxol hydrochloride)were each instilled in the trachea inner sleeve. Blood gas analysis was performed and the levels of serum lung surface active substances related protein-A (SP-A protein), interleukin-6, interleukin-8, tumor necrosis factor-alpha(TNF-α) were measured by enzyme linked immunosorbent assay (ELISA)before 1 d and after 3,7,14 d of tracheotomy. Results There were significant differences in arterial blood oxygen partial pressure, arterial carbon dioxide partial pressure, oxygenation index after 14 d of tracheotomy between ambroxol hydrochloride group and 0.45% sodium chloride group:(110.72±26.75) mmHg(1 mmHg=0.133 kPa) vs.(89.39±21.98) mmHg, (30.44±6.75) mmHg vs. (35.12±7.28) mmHg, 333.23±80.56 vs. 270.93±77.21,t=29.49,-8.63,7.44,P<0.01.There were significant differences in the levels of serum SP-A protein, interleukin -6, interleukin -8, TNF-α after 14 d of tracheotomy between ambroxol hydrochloride group and 0.45% sodium chloride group:(191.34±1.21) ng/L vs. (61.92±12.0) ng/L, (2.62±0.23) ng/L vs.(5.42±0.16) ng/L,(124.56±2.10) ng/L vs. (185.91±1.48) ng/L, (31.32±1.38) ng/L vs.(69.13±1.16) ng/L,t=75.72, -13.51, -23.89, -20.97,P<0.01. Conclusions The airway humidification effect of ambroxol hydrochloride group is better than 0.45% sodium chloride group, it can improve the wetting effect, and better protect the lung tissue, reduce the incidence of lung infection, make it an ideal airway humidification liquid. Key words: Craniocerebral trauma; Tracheotomy; Ambroxol; Pulmonary surfactant-associated protein A; Airway humidification