Effect preventive of aqueous extract Portulaca oleracea on haematological and histological changes of liver and kidneys in male mice exposed to copper sulphate poisoning.

Abstract

The current study was designed to observe and test the preventive for Portulaca oleracea aqueous extract on blood parameters and histological changes of liver and kidneys in in males albino mice that exposed to copper sulphate poisoning (40 mg / kg bw) for 30 days. The animals were divided into (3) groups containing five (5) animals and weighing (20-24 gm). The results of oral administration with copper sulphate showed significant decrease in (P <0.05) in body weight and organ count, which included (kidney, heart, liver and testicles), WBCs, LYM, MON, RBCs, HCB, HCT, MCV, MCH and MCHC. And significantly increased (P <0.05) in the spleen, GRAN, PLT ALP, AST and ALT compared with the control group. The results of the oral dose of Portulaca oleracea + copper sulphate showed a positive effect for these values compared with the group given copper sulphate. The oral administration of copper sulphate causes satisfactory tissue changes in the liver and kidneys of male white rats. The tissue is Destruction (DS) around the central vein (CV) with the pool of inflammatory cells (IF) and the presence of congestion (CON) in the liver and the presence of Haemorrhage (H) Hayline cast (HYC) in some urinary tubules also shows a collection of inflammatory cells (IF) in the kidneys. And treatment with Portulaca oleracea +copper sulphate showed the return of hepatocytes (HC) and central vein (CV) to normal as can be seen Sinusoids (S). The renal Glomerulus (G) and proximal and distal urinary bulb (UT) were normal compared with the copper sulfate control group.