Abstract
The role of serum levels on the intracortical accumulation kinetics of gentamicin was evaluated in normal and Enterococcus faecalis-infected kidneys using a short term infusion model in conscious rats. Female Sprague-Dawley rats were infused over a period of 6 h with gentamicin achieving individual steady-state serum levels ranging from 0.5 to 20 μg/mL. Pyelonephritis was induced by a direct inoculation of the left kidney with a suspension of E faecalis. This model resulted in severe infection of the left kidney and mild infection of the right kidney. Gentamicin cortical concentrations were analyzed as a function of serum levels by linear regression (least squares regression analysis). Steady-state elevation of serum concentrations of gentamicin was associated with a linear increase of cortical concentrations in normal, and in both left and right infected kidneys. No significant difference in the kinetics of gentamicin uptake was observed between normal and right and left infected kidneys. Therefore, E faecalis pyelonephritis does not modify the intracortical accumulation kinetics of gentamicin.
Highlights
The role of serum levels on the intracortical accumulation kinetics of gentamicin was evaluated in normal and Enterococcus jaecalis-infected kidneys using a short term infusion model in conscious rats
This study shows that the intracortical uptake and kinetics of gentamicin were not modified in the presence of infection
The accumulation kinetics of gentamicin were linear as steady-state serum levels varied from 0.5 to 20
Summary
The role of serum levels on the intracortical accumulation kinetics of gentamicin was evaluated in normal and Enterococcus jaecalis-infected kidneys using a short term infusion model in conscious rats. Pyelonephritis was induced by a direct inoculation of the left kidney with a suspension of E jaecalis. No significant difference in the kinetics of gentamicin uptake was observed between normal and right and left infected kidneys. Beauchamp et al [7] and Bergeron et al [6] observed higher intracortical gentamicin concentrations in Escherichia coli-infected kidneys compared to normal kidneys. These changes, observed in the presence of Gram-negative infection, Service d"lrifectiologie.
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