Effect of zoledronic acid used in the root surface treatment of late replanted teeth: a study in rats

Graziela Garrido Mori,Daniele Clapes Nunes,Daniela Maria De Mendonça Janjacomo,Lithiene Ribeiro Castilho

doi:10.1590/s0103-64402010000500013

Graziela Garrido Mori, Daniele Clapes Nunes + Show 2 more

Open Access

https://doi.org/10.1590/s0103-64402010000500013

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Abstract

This study evaluated the use of zoledronic acid, a resorption inhibitor, as a medication for root resorption treatment of late replanted teeth. Twenty-four maxillary right central incisors of rats were avulsed and kept dry for 30 min. Then, the teeth were divided into 2 groups. In group I, root surface was treated with 2% sodium fluoride for 20 min; in group II, 10-6M zoledronic acid solution was used for 20 min. All root canals were filled with calcium hydroxide. Next, teeth were replanted in their respective sockets. After 15 and 60 days post-replantation, the animals were killed and the anatomic pieces were obtained and prepared for microscopic and morphometric analyses. The results showed that zoledronic acid was capable of limiting the occurrence of root resorption and preserving cementum resorption. Further research must be performed to confirm the use of zoledronic acid in root surface treatment of late replanted teeth.

Highlights

Tooth avulsion, characterized by the complete displacement of the teeth from its alveolus, accounts for nearly 0.5 to 16% of dental trauma [1]
To achieve tooth replantation success, it is fundamental to maintain the vitality of the cells over the root [1]
Based on the aspects presented, the purpose of this study was to evaluate the effect of zoledronic acid solution when applied for root surface treatment of teeth submitted to late replantation

Summary

Introduction

Tooth avulsion, characterized by the complete displacement of the teeth from its alveolus, accounts for nearly 0.5 to 16% of dental trauma [1]. Several tissues may be affected or damaged, including: periodontal ligament, alveolar bone, gingiva, lips, and dental pulp [1]. The vascular-nervous bundle that supplies dental pulp is disrupted, leading to its necrosis [1]. These aspects have characterized dental avulsion as a complex traumatic lesion of difficult treatment [2]. To achieve tooth replantation success, it is fundamental to maintain the vitality of the cells over the root [1]. Either immediate replantation [1], performed within 15 min after avulsion, or storage of avulsed teeth in compatible media for the survival of those cells before replantation [1], is an imperative procedure

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