Abstract
Competitive inhibitors of carboxypeptidase A, 2-(4-imidazoyl)hydrocinnamic acid ( 1) and its congeners ( 2– 4) that bear an imidazole ring as the zinc-ligating functionality have been evaluated for their CPA inhibitory activity in the presence of zinc ion to find that the zinc ion augments the inhibitory potency by up to 212-fold.
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