Abstract
This study was conducted to investigate the effect of zinc in dose 15mg/kg.bw daily taken by the mouth and dexamethasone 4mgIkg.Bw by injection for 30days on some hematological biochemical tests and some histological changes of liver spleen in male rabbits. Thirty rabbits were used that divided into 3 randomized groups (each group contain 10 male rabbits ). Control group was taken normal food and water, Zinc group that gave zinc at dose of 15mg/kg.BW/daily/oral on 1, 2, 3, 4 weeks. Dexamethasone with zinc group : Employ dexamethasone 4mg/Kg.Bw . I.M dialy for 1 and 2 weeks for experiment and at 3, 4th weeks they gave zn 15mg/lKg.Bw day/orally. Blood samples were taken from the heart directly in 2 and 4weeks to examine packed cell volume (pcv), white blood cells (WBCs), Red blood cells (RBCs) with differential Leuckcyte count.separation blood collection to plasma and examine glucose mg/dl , cholesterol mg/dl. In histological tests, rabbits were killed and separate their organs tissue from the body to examine liver and spleen. The results revealed a decrease in level of RBCs, pcv after treatment with zinc 15, mg/Kg.Bw orally (zinc group) and increase in WBCs with differential leuckocyte count specially neutrophil cell, while biochemical tests show increase in glucose and cholesterol levels after treatment with dexamethasone 4mglkgBw. I/M seen increase in counts of RBCs , PCV, WBCs and differential lenkocyte count and decrease in glucose with cholesterol parameters, histological changes show change in liver after treatment by dexamethasone 4mglKg.Bw ,spleen tissue seen necrosis and pigmentation with hemorrhage after take dexamethasone 4mglkg in (dexamethasone + zinc group). Results also showed that zinc enhanced the immune system in at normal dose for limited time because of its effect on other mineral such as copper and causes anemia , while the dexamethasone is a drug used for antianflammatory but for a short time.
Highlights
(22).Bortezomib plus dexamethasone as induction treatment prior to autologous steam cells transplantation in patient with newly diagnosed multiple myeloma (22).It maybe given to woman at risk of delivering prematurely to promote maturation of fetus Lungs (6), It is used to treatment of high altitude cerebral edema(HACE) as well as high altitude pulmonary edema (HAPE) (9) .In veterinary use combined with marbofloxacin and clotrimazole and is available under the name
MATERIAL AND METHODS: In this study we stable 30 male rabbits in Animal houses stabling under normal condition air and heat .which divided into 3 groups:Control group : no treatment, Zinc group : which was given zinc 15 mg/kg.Bw(46) in 1,2,3,4 weeks orally.,Dexamethasone and zinc group : in this group treat with dexamethasone 4 mglkg.Bw(45) I.M in 1,2 week and in 3,4 week was given Zn15mg/kg.Bw orally
White blood cells :Data in table (3) appear that white blood cells (WBCs) increase significantly (p
Summary
Zinc is a trace mineral essential to all forms of life because of its fundamental role gene expression cellwith symbol [Zn] and atomic number 30(20), and chemically similar to magnesium , common oxidation state +2 ,the largest mineable on amounts are found in Australia , Asia ,United state (7) which is analloy of copper and zinc has been used in science at least 10th century Bc in Judea & by 7th century inancient Greece (16).Zn is an essential mineral perceived by the public today is being of exceptional biological and public health importance especially regarding prenatal and postnatal development (19).This mineral found in plants varies based on levels of the element in soil . when there is adequate in the soil, the food plants contains the most zinc are wheat (germ & brain) and Various seeds (sesame , poopy , alfalfa , celery, mustard)(14). Its found in beans , nuts , almonds , whole granis pumpkin seeds , sunflower seeds and black currant (41) Zn content of selection food per common measure.In human ,Zn plays ubiquitous biological roles and interactswith a wide range of 2 igands (19) with role in metabolism of RNA,DNA asingale transduction and gene expression (7) the function of zinc on the body,the body contains 1.5-2.5gm of zn ,its acomponents of every living cell and best known for its participation in enzyme structure and function .zn excellent for cell replication ,fertility and reproduction hormones activity, sexual maturation, night vision, immune function, cell growth, gene expressions,protein metabolism,hemoglobin activity.(23)The low amounts of zinc in the body causes children and women to developmental health problem recent studies show the low zinc deficiency causes attention deficient hyperactivity disorder ADHD in children and depression in women(10 )while the increasing zinc level with pharmacologic treatment according to studies will help to fix this problem(43 Dexamethasone : is atype of steroid medication (21) It is used in treatment of rheumatic problems , anumber of skin diseases , sever allergies , asthma , chronic obstructive lung disease , croup , brain swelling and along with antibiotics in tuberculosis (21). Aurison and treat difficult ear infection espically in dogs combined with trichlormethiazide to treat horses with swelling for distal limbs and general bruising (13)
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