Abstract
The aim of the study was to assess the impact of dietary zinc deficiency on functional T cells of the Peyer's patches (PP). One group of rabbits age and weight-matched with respect to control animals, was maintained on a zinc-deficient diet for 30 days. Before sacrifice, their body weights were recorded; blood hemoglobin, serum protein and serum zinc were determined. After sacrifice PP from the ileum of each animal were collected, counted and weighed. Rosette-forming cells in the lymphoid tissues were determined. The gut-associated lymphoid tissues (GALT) were significantly reduced in number and in weight in the zinc-deficient animals compared to control animals. Rosette-forming cells in the lymphoid tissues of the same group were also significantly reduced. The results indicated that zinc deprivation in animals may influence the local immune system of the intestine.
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