Abstract
Although consequences of zinc deficiency have been recognised over the years, little attention has been paid to the potential consequences of excessive zinc. The effect of 25 and 50 mg Zn/kg administration along with a control were examined on immune responses in mice. This was associated with a reduction of lymphocyte stimulation response to phytohemagglutin and lymphocyte numbers in the spleen at the 50 mg Zn/kg group. Leucocyte cell counts in both blood and spleen were also effected at the 50 mg Zn/kg group. CD8 and Thy 1.2 cell numbers were also affected in spleen and blood at the 50 mg Zn/kg group, but CD3 and CD4 were not affected by the two zinc concentrations. Serum zinc levels were significantly higher at the two zinc concentrations and dropped significantly over a period of time. J. Trace Elem. Exp. Med. 10:155–162, 1997. © 1997 Wiley-Liss, Inc.
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