EFFECT OF ZEPHIRAN CHLORIDE, TYROTHRICIN, PENICILLIN AND STREPTOMYCIN ON CILIARY ACTION

Abstract

THIS study was made to determine what effect, if any, solutions of zephiran chloride, tyrothricin, penicillin and streptomycin have on the ciliary activity of the mucous membranes of the upper respiratory tract. MATERIALS AND METHODS The Animal Used .—Twenty normal healthy rabbits were used for the entire study. Five were utilized for each of the four drugs in question. Preparation of the Mucous Membranes .—The ciliated mucous membranes were studied by two methods. In one they were extirpated and placed in the solutions in question. In the other they were left intact and bathed with the solutions that were being tested. For removal of the ciliated mucosa the animal was given a lethal dose of either pentobarbital sodium or ethyl carbamate U.S.P. (urethane) intravenously. A midline incision of the skin of the nose was made, following the bridge throughout its entire length. The periosteum was elevated and the bones covering the nasal