Abstract
Recently, it was reported that YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) is a new selective Na+/Ca2+ exchange (NCX) inhibitor (Iwamoto and Kita, 2006). We examined the effect of YM-244769 on the NCX current in isolated guinea pig ventricular myocytes with the whole-cell voltage-clamp technique. YM-244769 suppressed the bi-directional NCX current in a concentration-dependent manner. The IC50 values of YM-244769 were 0.12 μM and 0.1 μM for the bi-directional outward and inward NCX current, respectively, with a Hill coefficient of 0.7 and 0.8 for the bi-directional outward and inward NCX current, respectively.
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