Abstract
In this work, we investigated the effect of yttrium(Y) on microstructure, the mechanical and corrosion properties and the cytotoxicity of Zn-1.5Mg-xY(x=0, 0.2, 0.5wt%) alloys prepared by casting and extrusion. The results showed that the microstructure of extruded Zn-1.5Mg-xY alloys consisted of α-Zn matrix, Mg2Zn11 particles and Y containing blocks. The tensile strength and compressive strength of Zn-1.5Mg-xY alloys improve with the increase of Y content. Alloying with Y also had an impact on the corrosion resistance of Zn-Mg alloys. In terms of toxicity, the cells cultured in the leachate of Zn-1.5Mg-xY alloys with concentrations of 25% and 50% showed good growth morphology with the relative proliferation rate (RGR) values being greater than 100% and the cytotoxicity level being 0, the addition of Y has little effect on the compatibility of alloy with cells.
Highlights
Metallic biomaterials, such as stainless steel, titanium alloys and Fe-based alloys are widely used in making loadbearing medical implants.[1]
The yttrium containing phase is undetected by X-ray diffraction (XRD), because of its low content and the low sensitivity of the device
The results show the cells cultured in 25% and 50% extracts are in good condition and no dead cells are observed
Summary
Metallic biomaterials, such as stainless steel, titanium alloys and Fe-based alloys are widely used in making loadbearing medical implants.[1]. In the perspective of corrosion resistance, Zn and Zn alloys are expected to show an appropriate degradation rate.[2] Besides, Zn is an essential trace element in human body,playing important roles in many biological processes in human organisms, and meet the safety requirement for biomedical use.[3,4,5] Bowen et al.[6] placed pure Zn wires into the arteries of rats and they degraded at a rate just below 0.2 mm per year—the “magic” value for bio-absorbable stent—for the first three months. Zn alloy still suffer from the problem of low mechanical properties. In order to overcome the problem of low strength and low hardness of pure zinc, adding alloying elements would be an appropriate way to adjust microstructure and mechanical prperties
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