Effect of Xiaoyutang Combined with Intraperitoneal Heat Perfusion Chemotherapy on Immune Function, Circulating mir, Prognosis, and Survival of Postoperative Patients with Colorectal Cancer.

Lingxia Li,Xiaowan Huang,Osamah Ibrahim Khalaf,Jian Sun,Yunjiu Wang,Jue Zhang

doi:10.1155/2021/1619809

Abstract

Objective To explore the effects of Xiaoyutang combined with intraperitoneal heat perfusion chemotherapy on immune function, circulating Mir, and prognosis and survival of postoperative patients with colorectal cancer. Methods A total of 96 patients with colorectal cancer who were treated in our hospital from May 2018 to August 2019 and followed up to August 2021 were selected as the study subjects. The patients were randomly divided into a control group and study group by a 1 : 1 random number table method, 48 cases in each group. Patients in the control group were given intraperitoneal thermal perfusion chemotherapy after surgery, and patients in the research group were treated with Xiaoyutang on this basis. The treatment cycle was 21 days, and all patients were treated for 3 consecutive cycles. The therapeutic efficacy, immune function (CD3+, CD4+, and CD4+/CD8+), circulating mir (mir-29a, mir-145, and mir-92a), prognosis, and survival of the two groups were compared. Results After 3 cycles of treatment, ORR and DCR in the study group were higher than those in the control group (60.42% vs. 37.50%) and 85.42% vs. 66.67%, respectively, with statistical significance (P < 0.05). There were statistically significant differences in CD3+, CD4+, CD4+/CD8+, mir-29a, mir-145, and mir-92a time points and intergroup and intergroup interactions between the two groups (P < 0.05); the levels of CD3+, CD4+, and CD4+/CD8+ in the study group were higher than those in the control group after 1, 2, and 3 cycles of treatment (P < 0.05); the expressions of mir-29a, mir-145, and mir-92a were significantly lower than those in the control group (P < 0.05). By the end of follow-up, 3 cases were lost to follow-up in the study group and 5 cases in the control group. The recurrence rate and mortality of the study group were lower than those of the control group at 1- and 2-year follow-up (P > 0.05), and the mean survival time of patients in the study group was higher than that in the control group; the differences were statistically significant (χ2 = 5.151, P = 0.023). Conclusion Xiaoyutang combined with peritoneal heat perfusion chemotherapy has a good postoperative effect on patients with colorectal cancer, which can effectively improve the immune function and circulating Mir of patients with colorectal cancer, reduce tumor recurrence, and improve the prognosis of patients.

Highlights

The causes of colorectal cancer are mostly related to lifestyle, genetics, colorectal adenoma, and other factors
This study investigated the effects of Xiaoliu Decoction combined with intraperitoneal thermal perfusion chemotherapy on immune function, circulating Mir, and prognostic survival of postoperative patients with colorectal cancer, in order to provide reference for the treatment of rectal cancer
The selected patients were randomly divided into a control group and study group at 1 : 1. There was no significant difference in baseline data between the two groups (P > 0:05) (Table 1)

Summary

Introduction

The causes of colorectal cancer are mostly related to lifestyle, genetics, colorectal adenoma, and other factors. With the progress of the disease, there is no opportunity for surgical treatment in the late stage. The survival rate within 5 years is only about 5%, which can seriously threaten the life and health of patients [1]. Surgical treatment is one of the treatment methods for patients with colorectal cancer, but surgery cannot eradicate tumor cells, resulting in residual tumor metastasis and recurrence, which affects the prognosis. Chemotherapy is an effective adjuvant treatment for colorectal cancer after operation, but affected by the peritoneal plasma barrier, only a small number of chemotherapy drugs can enter the abdominal cavity through intravenous chemotherapy, so the killing effect of free cancer cells in the abdominal cavity is poor [2].

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Results

Conclusion