Abstract
To investigate the effects of Xiaoning liquid on gut microbiota in mouse during asthma. A total of 60 mice were randomly and averagely assigned to healthy control group, control group, budesonide group, and Xiaoning liquid group. The later three groups were used to establish an Ovalbumin (OVA) asthma model. The intestinal bacterial communities were compared among groups using 16S rRNA gene amplification. Analyzing the structure of gut microbiota with OTU analysis, Shannon-Wiener, PCA, PCOA, etc. 16S rDNA high- throughput sequencing. The abundance and diversity of the gut microbiota in asthmatic mice increased, most obviously in the control group. The Bacteroidetes and Firmicutes levels increased in all asthmatic mice. The level of Bacteroides increased most obviously, making Bacteroides a useful marker of gut microbiota changes in asthmatic mice. The levels of Proteobacterium, Deferribacteraceae and Mucispirillum dropped significantly in the Xiaoning liquid group. Xiaoning liquid can reduce the species and numbers of pathogenic bacteria and restored the intestinal microecology of asthmatic mice. Xiaoning liquid has a positive effect on the function of gut microbiota.
Highlights
Asthma is a chronic inflammatory disease of the respiratory airways characterized by an inappropriate immune response resulting in reversible airflow obstruction, airway hyper‐responsiveness (AHR), mucus overproduction, tissue eosinophilia, and intense airway wall remodeling (Noval Rivas et al, 2016)
This bacterial dysbiosis was confirmed in other studies of the same group of authors, in which they showed the relative abundance of the bacterial genera Lachnospira and the decrease of Veillonella, Faecalibacterium, and Rothia in children at risk of asthma (Arrieta et al, 2016)
We investigated the relationship between intestinal flora and asthma with a traditional Chinese medicine (TCM), Xiaoning liquid
Summary
Asthma is a chronic inflammatory disease of the respiratory airways characterized by an inappropriate immune response resulting in reversible airflow obstruction, airway hyper‐responsiveness (AHR), mucus overproduction, tissue eosinophilia, and intense airway wall remodeling (Noval Rivas et al, 2016). Studied a population of children diagnosed with asthma at preschool age in whom they found evidence of gut bacterial dysbiosis (Watson et al, 2019), and a reduction of Lachnospira in favor of Clostridium spp. was potentially linked to asthma. This bacterial dysbiosis was confirmed in other studies of the same group of authors, in which they showed the relative abundance of the bacterial genera Lachnospira and the decrease of Veillonella, Faecalibacterium, and Rothia in children at risk of asthma (Arrieta et al, 2016)
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