Effect of Xiangsha Pingweisan on gastric emptying motility in mice

Abstract

AIM:To evaluate the effects of Chinese herbs Xiangsha Pingweisan (XSPWS) decoction and its component on gastric emptying in healthy mice. METHODS:Mice were randomly divided into control group, cisapride group and XSPWS group. The effects of XSPWS on gastric emptying were investigated in vivo by measuring gastric remainder rates of Blue Dextron (BD) 2000. Additionally, the effect of each component herb in XSPWS recipe was evaluated in the same way according to orthogonal design. RESULTS:Compared with control group [(100.0±24.2) %], the rates of gastric remainder in XSPWS group [(39.5±18.3) %] and cisapride group [(36.9±16.4) %] were all significantly decreased (P 0.05). Except radix glycyrrhizae preparta group, the gastric emptying rates of other component herbal groups were significantly higher than that of control group (P <0.01). Based on the analysis of orthogonal design, there were wide–ranging first–grade mutual roles within the six component herbs. CONCLUSION:XSPWS and its some component herbs can accelerate the gastric emptying in mice in vito significantly. There are wide–ranging first–grade mutual roles within the six component herbs.