Abstract
AbstractThe effects of the xenobiotics atrazine, benzene, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), lindane, toluene, and xylenol on the respiration of isolated rat heart mitochondria were studied. Bioenergetic parameters such as respiratory control (RC) and ATP /oxygen (P/O) values decreased considerably in the presence of these substances, and a concomitant increase of superoxide radical (O2−) formation was observed. These observations were discussed in terms of partial damage of the inner mitochondrial membrane, impairing the maintenance of the proton gradient across this membrane. In the presence of protons, ubisemiquinone radicals (UQ −) present in the inner mitochondrial membrane are able to react with molecular oxygen, thereby generating superoxide radicals. The changes of membrane potential and P/O values show a linear inverse correlation with O2− formation rates, whereas this correlation with RC values was not linear.
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