Abstract
Article History Tea is the second most popular drink in the world after water, and many studies have highlighted the effects of drinking tea. Therefore, the aim of this study was to explore the effects of white tea extract on the antioxidant enzymes activity including superoxide dismutase (SOD), glutathione peroxidase (GSH-px), and catalase (CAT). A significant decrease was observed in serum and liver SOD, GSH-px, and CAT activities in the diabetic control rats compared with the nondiabetic control ones. However, a significant increase in SOD, GSH-px, and CAT activities (serum and liver) was observed in the diabetic groups treated with white tea extract or Glibenclamide as compared to the diabetic control group. In conclusion, the present findings indicated that white tea extract has an enhancing effect on the antioxidant enzyme activities (SOD, CAT, and GSH-px) in STZ-induced diabetic rats.
Highlights
Diabetes mellitus is a non-curable but controllable chronic metabolic disorder characterized by a loss of glucose homeostasis with disturbances of carbohydrate, fat, and protein metabolism due to defects in insulin secretion, insulin action, or both (American Diabetes Association 2012; DeFronzo 2004; WHO 1999)
The present study showed a significant decrease (P
As diabetes and its complications are associated with free radical mediated cellular injury (Kaleem et al, 2006), an aqueous extract of white tea was administered to diabetic rats to assess their antioxidant potential
Summary
Diabetes mellitus is a non-curable but controllable chronic metabolic disorder characterized by a loss of glucose homeostasis with disturbances of carbohydrate, fat, and protein metabolism due to defects in insulin secretion, insulin action, or both (American Diabetes Association 2012; DeFronzo 2004; WHO 1999). Leads body tissues, mainly; the liver and muscle tissues fail to capture and utilize glucose from the blood circulation. This resulted in the increase of blood-glucose levels, a state known as hyperglycemia (American Diabetes Association 2012). The restrictions of currently existing drugs have motivated researchers to explore alternative antidiabetic therapy. Concern is given to plants and herbs used in traditional medicine as an antidiabetic treatment looking forward to discovering novel natural products that can be used as safe, cheap, and effective antidiabetic therapy (Kavishankar et al, 2011).
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