Abstract
This study was performed to elucidate the effect of whey hydrolysate formula on the transfer of an antigen into serum and milk. The concentrations of beta-lactoglobulin in serum and milk were positively correlated (p < 0.01). The concentration of beta-lactoglobulin in serum tended to become low in the mouse and to be accompanied with a high level of fecal anti-beta-lactoglobulin IgA concentration. The fecal anti-beta-lactoglobulin IgA of mice fed hydrolysate formula for 12 weeks was significantly higher than that of the control formula-fed mice (p < 0.05). These results suggest that a high level of intestinal IgA elicited by the feeding of hydrolysate formula may reduce the transfer of beta-lactoglobulin into serum and milk.
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