Abstract
BackgroundThe present study aims to clarify the effects of weight loss on biomarkers associated with angiogenesis in patients who underwent laparoscopic sleeve gastrectomy (SG) or adjustable gastric banding (LAGB) in the 12-month follow-up study.Materials and MethodsWe studied 24 obese patients who underwent laparoscopic weight loss surgery, 13 of whom underwent SG and 11 of whom underwent LAGB. We evaluated the circulating level of angiogenesis biomarkers preoperatively and 12 months after surgery.ResultsBefore surgery, the following angiogenic circulating factors were significantly higher than those of healthy subjects: angiopoietin 2 (ANG-2) (p < .05), granulocyte colony-stimulating factor (G-CSF) (p < .05), hepatocyte growth factor (HGF) (p < .01), platelet endothelial cell adhesion molecule (PECAM-1) (p < .01), and vascular endothelial growth factor (VEGF) (p < .05). The following angiogenesis biomarkers decreased significantly after weight loss compared with their baseline values: ANG-2 (p < .05), follistatin (p < .05), HGF (p < .01), PECAM-1 (p < .01), and VEGF (p < .05). There were no significant differences in the circulating levels of angiogenesis biomarkers between individuals who underwent SG and those who underwent LAGB; however, HGF, PECAM-1, and VEGF tended to be lower after SG. %BMI correlated negatively with HGF, PECAM-1, and VEGF. A similar significant negative correlation was found for %WL and %EWL. WHR correlated with PDGF-B and VEGF.ConclusionsWe concluded that weight loss surgery induces the changes of circulating levels of angiogenesis biomarkers in obese patients. The changes in angiogenesis status in obese patients who lost weight after bariatric surgery depended on the amount of weight loss.
Highlights
Obesity induces adipose tissue dysfunction that typically leads to the overexpression of proinflammatory adipokines, OBES SURG (2020) 30:3417–3425 controlling angiogenic origination and offered a potential homeostatic mechanism for regulating vascular density [9, 10]
We evaluated the impact on the venous hemodynamics of the femoral vein on angiogenesis status in morbidly obese patients and confirmed that circulating angiogenesis biomarkers were significantly higher in the obese patients compared with the control group
All of the angiogenesis parameters were higher in obese subjects, but significant differences were observed for angiopoietin 2 (ANG-2) (p < .05), granulocyte colony-stimulating factor (G-CSF) (p < .05), hepatocyte growth factor (HGF) (p < .01), PECAM-1 (p < .01), and vascular endothelial growth factor (VEGF) (p < .01)
Summary
Obesity induces adipose tissue dysfunction that typically leads to the overexpression of proinflammatory adipokines, OBES SURG (2020) 30:3417–3425 controlling angiogenic origination and offered a potential homeostatic mechanism for regulating vascular density [9, 10]. Physiological angiogenes are necessary to correct the functions of some organs, but an altered mechanism involving angiogenesis leads to the formation of new blood vessels and contributes to various diseases, including malignant, ischemic, and inflammatory disorders, which are associated with obesity [13]. The present study aims to clarify the effects of weight loss on biomarkers associated with angiogenesis in patients who underwent laparoscopic sleeve gastrectomy (SG) or adjustable gastric banding (LAGB) in the 12-month follow-up study. We evaluated the circulating level of angiogenesis biomarkers preoperatively and 12 months after surgery
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