Effect of weight loss on metabolic parameters in over-weight or obesity patients combined with impaired glucose tolerance

Abstract

Objective To evaluate the effective of weight loss on blood glucose, lipid profile, and blood pressure in over-weight or obesity patients combined with impaired glucose tolerance (IGT). Methods Body weight of 91 over-weight or obesity IGT patients were managed by doctors and nurses.Body weight, waist circumference, blood glucose, lipid profile, blood pressure and liver function of the patients were compared at 3 months with baseline. Results After 3 months' intervention, the levels of body weight, waist circumference, fasting plasma glucose, postprandial glucose, systolic blood pressure, diastolic blood pressure, and glutamic oxalacetic transaminase (GOT), instead of triglyceride and high-density lipoprotein cholesterol (HDL-C), were significantly reduced.Over weight or obesity IGT patients saw a 1.8 and 2.3 kg body weight loss, respectively.Decreased plasma glucose and blood pressure were found both in the over-weight group and in the obesity groups, but decreased waist circumference and GOT were found only in the over-weight patients. Conclusions Body-weight control may improve the blood glucose, blood pressure, central obesity, or fatty liver in over weight or obesity IGT patients.For those obesity patients, longer and stronger body weight control should be needed. Key words: Overweight; Obesity; Metabolism