Effect of weight loss on antioxidant enzymes and their relationship with the antioxidant vitamins A,C, E food intake in obese women

Abstract

General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Glutathione reductase and catalase activities showed a significant increase (P<0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between daily vitamin C intake with superoxide dismutase enzyme after intervention (P=0.004, r=0.507). There was a negative linear correlation between vitamin E intake and glutathione peroxidase activity before intervention (P=0.005, r=-0.5). A negative correlation was found between daily vitamin A intake and glutathione reductase enzyme before and after intervention (r=-0.385, r=-0.397, P<0.05) respectively. No significant correlation was observed between vitamins A, C, E amounts and catalase activity. Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women