Abstract
Oxygen and glucose uptakes and glycogen content of isolated rat diaphragm were studied in phosphate-saline medium containing 120 mg% glucose in the presence of moderate up to very high levels of various water-soluble vitamins. Of the significant findings, calcium pantothenate, methyl-methionine-sulfonium chloride, and ascorbic acid, each at a level of 0.75 mg, depressed oxygen uptake. At the latter concentration, inositol and pyridoxine hydrochloride caused a small but definite increase in the mean glycogen level, and PABA depressed both oxygen and glucose uptake by the muscle. More physiologically significant results were obtained with α-lipoic acid, which markedly decreased the glycogen content even at a level of 5 μg, and citrovorum factor (leucovorin; 10 μg), which strongly depressed both the glucose uptake and glycogen. The effect with citrovorum factor did not extend to folic or tetrahydrofolic acids, the three being compared at a level of 1.1 μ M.
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