Abstract
During the 1992-1995 siege, as well as after the war activities, citizens of Sarajevo were most probably exposed to various potential genotoxic agents. The effects of those potential genotoxins were evaluated by micronucleus-cytokinesis blocked assay. The study included 30 individuals who resided in the area of Sarajevo during the war and the postwar period. Point bi-serial coefficient analysis did not reveal any relationship between the frequencies of binuclear cells with micronuclei as well as total number of micronuclei and smoking habits or gender. Simple linear regression revealed statistically significant positive correlation between the age and micronuclei formation. Due to the war related environmental contamination more extensive study is recommended.
Highlights
According to The Study of the Battle and Siege of Sarajevo average daily shell impact, over the course of the siege, is estimated at approximately ( )
In the present study we aimed at the evaluation of genetic load, expressed as micronuclei formation in peripheral blood lymphocytes of individuals potentially exposed to various war and post-war genotoxins
Citizens of Sarajevo were exposed to products of ammunition degradation, contaminated food, water and pharmaceuticals, when we compared results with our previous findings we verified that Sarajevo study group has lower frequency of micronuclei that human group exposed to depleted uranium
Summary
According to The Study of the Battle and Siege of Sarajevo average daily shell impact, over the course of the siege, is estimated at approximately ( ). During the NATO air strikes in and localities near Sarajevo were hit by radioactive shells containing depleted uranium. SLAVKA IBRULJ ET AL.: EFFECT OF WAR AND POSTWAR GENOTOXINS ON MICRONUCLEI FREQUENCY IN SARAJEVO STUDY GROUP contaminators present is still high. Peripheral blood lymphocytes are practical for observation of cytogentic biomarkers, such as micronuclei, even several years after the exposure. Due to the life span of human T-lymphocytes (estimated at , to years) micronuclei formation in those cells provide information on genetic damage accummulated during their lifetime ( , ). In the present study we aimed at the evaluation of genetic load, expressed as micronuclei formation in peripheral blood lymphocytes of individuals potentially exposed to various war and post-war genotoxins
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