Abstract
The effect of varying wall flexibility on the deformation of an artery during steady and pulsatile flow of blood is investigated. The artery geometry is recreated from patient-derived data for a stenosed left coronary artery. Blood flow in the artery is modeled using power-law fluid. The fluid-structure interaction of blood flow on artery wall is simulated using ANSYS 16.2, and the resulting wall deformation is documented. A comparison of wall deformation using flexibility models like Rigid, Linear Elastic, Neo-hookean, Mooney-Rivlin and Holzapfel are obtained for teady flow in the artery. The maximum wall deformation in coronary flow onditions predicted by the Holzapfel model is only around 50% that predicted by the Neo-Hookean model. The flow-induced deformations reported here for patient-derived stenosed coronary artery with physiologically accurate model are the first of its kind. These results help immensely in the planning of angioplasty.
Highlights
IntroductionFew studies have incorporated such representative models of arteries when simulating blood flow: most studies prefer to use approximations like thin-shell [6], Linear Elastic model [7], Neo-Hookean [8], Mooney-Rivlin model [9], or modified Mooney-Rivlin model [10] for the artery wall
Arteries in which atherosclerotic plaques have grown and block the lumen are known as stenosed arteries
We implement a fluid-structure interaction approach wherein we study blood flow in a stenosed artery with the artery walls being flexible
Summary
Few studies have incorporated such representative models of arteries when simulating blood flow: most studies prefer to use approximations like thin-shell [6], Linear Elastic model [7], Neo-Hookean [8], Mooney-Rivlin model [9], or modified Mooney-Rivlin model [10] for the artery wall. Such studies [10,11] have typically concerned themselves with obtaining stress distributions in the arterial cross-section and overlapping them with plaque composition so as to gain insights into the effect of plaque composition on stress distribution and possible rupture. Wall deformation of arteries is a key parameter that needs to be evaluated prior to, and during, revascularization using angioplasty, and it is best evaulated using a physiologically accurate model like that in [12]
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