Abstract
The aim of the present study is to evaluate the effect of voluntary wheel running on striatal dopamine level and behavior of cognition and emotion in molar loss rats. Twenty-four Sprague-Dawley rats were enrolled in this study and randomly divided into following 4 groups: control group (C group), molar loss group (ML group), 1-week physical exercise before molar loss group (1W-ML group), and 4-week physical exercise before molar loss group (4W-ML group). The rats both in 4W-ML and 1W-ML groups were placed in the voluntary running wheel in order to exercise for 4 weeks and 1 week, respectively. Then, the rats in 4W-ML, 1W-M, and ML groups received bilateral molar loss operation. After 10 days, striatal dopamine level was detected by in vivo microdialysis coupled with high-performance liquid chromatography (HPLC) and electrochemical detection. All the rats received behavior test after microdialysis detection. The behavior tests including passive avoidance test were used to assess cognition and elevated plus maze test for emotion. The results indicated that voluntary wheel running promoted striatal dopamine level in rats of molar loss. Behavioral data indicated that voluntary wheel running promoted cognition and emotion recovery after molar loss. Therefore, we concluded physical exercise significantly improved the neurocognitive behaviors and increased the striatal dopamine level after molar loss in rats.
Highlights
It is well established that tooth loss is a known risk factor of Alzheimer’s disease (AD) [1]
Previous research used passive avoid test to evaluate cognition, which shows that molar loss may cause accumulation of the amyloid cascade in the brain that leads to cognitive impairment [38]
We demonstrated that molar loss-induced cognitive and emotive impairments are associated with the decrease of striatal dopamine level
Summary
It is well established that tooth loss is a known risk factor of Alzheimer’s disease (AD) [1]. Animal research demonstrated that molar loss can cause the functional deterioration of cognition [6]. Previous studies have demonstrated that the rat with molar loss broke the balance of the cholinergic neuronal system and caused the impairment of cognition [7]. A preliminary quantitative study revealed that wide range of emotional effects was caused by tooth loss, such as loss of self-confidence and anxiety [8]. Further studies have shown that physical exercise, aerobic fitness exercise in had a positive effect on multiple aspects of brain function [9,10,11]. Numerous studies have shown that dopamine degeneration caused significant alteration in cognitive and emotive function by medicating striatal dopamine pathways [21,22]. Degeneration of dopamineproducing neurons in striatum complex leads to diminished
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