Abstract
1. 1. The effect of vitamin(vit) K 3 on guinea-pig macrophage functions was studied. 2. 2. Vit K 3 inhibited macrophage locomotion, phagocytosis and lysosomal enzyme release. 3. 3. Vit K 3 inhibited the rise in the intracellular free calcium level induced by stimuli at the concentration at which vit K 3 supressed functions. 4. 4. These results suggest that vit k 3 inhibits macrophage functions through the interference with the mobilization of intracellular calcium.
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