Abstract
Background: Tooth movement induced by the application of orthodontic force was initiated by inflammatory process.Studies have shown that vitamin E has an anti-inflammatory andantioxidantpropertieswhich perhaps could inhibit the tooth to move.This study aimed to evaluate the effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats. Methods: Wistar rats (n=56) were divided into two groups. Group 1 served as the control groups, while group 2 was given vitamin E for 14 days before application of orthodontic force. Each group was divided into four subgroups (n=7), corresponding to the number of days orthodontic force lasted, i.e. 0, 1, 3, 7 days. At each of these four time points, distance measurements and quantity of osteoblasts-osteoclasts were measured in each rat. Results: Tooth movement distance was increased for group 2 than group 1 for all time intervals, but this difference was only statistically different on day 3 ( p=0.001). For both groups, tooth movement was significantly different between each time interval in each group ( p=0.041). The mean number of osteoblast cells was increased for group 2 compared to group 1 for all time intervals (p<0.05), but was not significant different between time intervals ( p=0.897). The number of osteoclasts was not significantly different between groups, but it was statistically different between time intervals (p=0.004). Conclusion: The outcome of this study demonstrated that group 2 resulted a better tooth movement compared to group 1 and significantly found on day 3, based on the distance measurement. The osteoclast cell numbers were the same within both control groups, whilstthe number of osteoblast cells in group2was significantly higher than those in group 1.
Highlights
Tooth movement induced by the application of orthodontic force was initiated by inflammatory process
The purpose of this study was to evaluate the effect of vitamin E supplementation on tooth movement distance and osteoblast and osteoclast cells in Wistar rats
Throughout the feeding of Vitamin E or tochoperols (VE) supplementation, all rats were habituated to reduce their stress-related disturbances and they seemed to be in a good condition during administration of VE, and no rat had undergone for toxicity and neither had been death within the experimental period
Summary
Tooth movement induced by the application of orthodontic force was initiated by inflammatory process. Each group was divided into four subgroups (n=7), corresponding to the number of days orthodontic force lasted, i.e. 0, 1, 3, 7 days. At each of these four time points, distance measurements and quantity of osteoblastsosteoclasts were measured in each rat. Results: Tooth movement distance was increased for group 2 than group 1 for all time intervals, but this difference was only statistically different on day 3 (p=0.001). The number of osteoclasts was not significantly different between groups, but it was statistically different between time intervals (p=0.004). Conclusion: The outcome of this study demonstrated that group 2 resulted a better tooth movement compared to group 1 and significantly found on day 3, based on the distance measurement. The osteoclast cell numbers were the same within both control groups, whilst the number of osteoblast cells in group 2 was significantly version 3 (revision)
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