Abstract
The aims of this research were: a) to determine the protective effect of vitamin E in the low density lipoprotein concentration and aorta , b) to give information, especially in the relationship between the high fat diet and the incidence of cardiovascular diseases. Twenty five male wistarrats weighing 200–250 grams at the age of 3 months were used in this study. Completely randomized design was implemented for thisexperiment. The rats were acclimated for a week and fed with CP 521 (basal). The rats were then randomly allotted into 5 groups, 5 sampleseach. The rats were fed basal (CP 521) as control (G I), high fat diet (CP 521 + palm oil 10%) + 50 IU vitamin E (G II), high fat diet fat + 100IU vitamin E (G III), high fat diet + 200 IU vitamin E (G IV) and high fat diet + 400 IU vitamin E (G V). Diets were given about 10% of bodyweigh and it’s fed up every day. Water was given ad libitum. Based on statistically analysis showed that very significance (P0,01) between thetreatment. Result indicated that given high fat diet + 400 IU vitamin E could apparently reduce LDL concentration, Lesion in the aortaconsisting of hemorrhagic and hyperemic were found in all rats receiving high fat diet supplemented with less than 400 IU vitamin E. The ratsreceiving high fat diet + 400 IU vitamin E (G V) the aorta were normal. It was concluded that the diet containing high fat and high vitamin Esupplementation (400 IU ration) in the diet could protected the incidence of atherosclerosis.____________________________________________________________________________________________________________________Key words: atherosclerosis, high fat diet, vitamin E,
Highlights
Konsumsi lemak tinggi yang berlebihan akan tercermin dalam serum darah
200–250 grams at the age of 3 months were used in this study
Completely randomized design was implemented for this experiment
Summary
Razali Daud1 1Laboratorium Klinik Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh. Penelitian ini bertujuan menguji pengaruh perlindungan dari vitamin E terhadap konsentrasi low density lipoprotein (LDL) dan aorta dan mengetahui hubungan antara ransum lemak tinggi dengan insiden penyakit kardiovaskuler. Hasil pengamatan secara mikroskopik lesi pada aorta terlihat adanya hemoragi dan hiperemi yang ditemukan pada semua tikus putih yang diberi ransum lemak tinggi yang disuplemen vitamin E kurang dari 400 IU. Tikus yang diberi ransum lemak tinggi + vitamin E 400 IU (KV) terlihat aortanya normal. Dapat disimpulkan bahwa pemberian ransum lemak tinggi + 400 IU vitamin E mampu melindungi terhadap tidak terjadinya peningkatan konsentrasi LDL dan mampu melindungi untuk tidak terjadinya aterosklerosis. Menurut Shireman (1996), Jialal dan Devaraj (1996), lesi pada aorta terjadi akibat adanya low density lipoprotein (LDL) teroksidasi yang merusak jaringan pembuluh darah dan menarik sel-sel darah putih menuju ke daerah nekrosis. Vitamin E, terutama α-tokoferol merupakan salah satu vitamin yang larut dalam lemak yang memiliki fungsi sebagai antioksidan (Stickel et al, 1997), yang terutama diperankan oleh gugus hidroksil pada molekul vitamin E, antara lain tocopheronic acid, tocopheronic lactone, tocopheryl-p-quinone, dan tocopheryl
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