Abstract
Albino female rats were fed for 4 to 6 months on either a vitamin E-supplemented or on a vitamin E-unsupplemented diet. Of the urea cycle enzyme activities, carbamyl phosphate synthetase and ornithine transcarbamylase were significantly higher in the vitamin E-supplemented group than in the vitamin E-unsupplemented one. Reversely, the activity of ornithine-keto acid trans-aminase was lower in the former group. Urea level in the serum and liver was lower in the vitamin E-supplemented group, but urea excretion was accelerated in this group. Activity of isocitric dehydrogenase was significantly higher in the vitamin E-supple-mented group. From these results, it is suggested that vitamin E is efficient for the de-toxication of ammonia in the animal body.
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