Abstract
Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats
Highlights
Impaired wound healing events is a common complication in diabetes
Different treated groups reduced cellularity were seen in d-δ-tocotrienol-rich fraction (TRF) treated group than d-a-tocopherol and coadministrated treated groups (Fig. 4)
On 3rd weeks cellular components were more in control groups whereas these features were reduced in d-δ-TRF group than d-a-tocopherol and co-administrated groups. These results suggest that the dermal regeneration process was slow in control groups but the three weeks d-δ-TRF supplementation boost the early dermal regeneration as compared to d-α-tocopherol supplementation and co-administration
Summary
One of the effective nutritional antioxidant on skin wound healing is vitamin E which contains saturated tocopherol and unsaturated tocotrienol forms. This present study is designed to explore the effect of different vitamin E isoforms on stitched skin wound in both healthy and diabetic rats. Conclusion: It is concluded that among different vitamin E isoforms the d-δ-TRF appears to be a more effective nutritional antioxidant on skin wound healing in both healthy and diabetics. The antitumor activity of tocotrienols is not dependent on its antioxidant activity [9,10].The highly biopotent γ and δ- tocotrienols may play a physiological role in modulating normal cell growth, function and remodeling These compounds inhibit tumor growth without harming normal tissues [11,12,13,14]
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