Abstract
Impact of vitamin E against mercuric chloride (HgCL2) induced renal toxicity in Wister albino rats was studied. Feeding of the rats with diet and water contaminated with a non lethal dose of the mercuric chloride (20 parts per million) every other day for 42 days resulted in significant increase of serum malondialdehyde (MDA), which is an important biomarker of the oxidoreductive stress, and significant decline in each of the reduced glutathione (r-GSH) concentration, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzymes activities, which constitute a vital part of the endogenous protective antioxidant system, as compared to the control group. The study found that the simultaneous oral co administration of vitamin E (as α-tocopherol acetate) 100 mg/kg B.W. every other day for 42 days along with mercuric chloride produced a cardinal protective effects against the development of the mercuric chloride induced nephrotoxicity. This can be through reversing the elevated oxidative stress; induced by the administration of the HgCL2. In conclusion serum biochemical and kidney histopathological findings of the current study highlight the beneficial effects of vitamin E in rats with HgCl2-mediated renal toxicity.
Highlights
The prevalence of mercurial intoxication by food and environmental sources has risen in the world
On days zero and 43, blood samples were collected by puncture from the heart in clean test tubes, serum separated by centrifuging the blood samples at 4000 round per minute for 5 minutes to obtain the serum for the estimation of malondialdehyde (MDA) level as oxidative stress biomarker, reduced Glutathione (r-GSH) concentration, Glutathione peroxidase (GSH-Px) and Superoxide dismutase (SOD) activities as antioxidoreductive parameters
The administration of HgCl2 brings about renal dysfunction, which is evident in the current study by profound decrease in glutathione concentration and severe degenerations and coagulative necrosis in the renal tubules especially the proximal convoluted tubules (PCTs)
Summary
The prevalence of mercurial intoxication by food and environmental sources has risen in the world. Alpha-tocopherol acetate (Vitamin E) was noticed as the most effective fat soluble antioxidant and had been known to explore a helpful ameliorative role in some disease processes It protects the body's biological systems due to preventions of lipid peroxidation by scavenging free radicals ability in lipoprotein membranes [15]. The current study was designed to evaluate the possible renal pathophysiologic changes due to oxidoreductive stress that chronic exposure to inorganic mercury in low doses may cause at tissue and biochemical levels. It attempts to assess the possible antioxidoreductive stress protective impact of using vitamin E as α-tocopherol acetate against HgCl2 induced lipid peroxidation mediated nephrotoxicity in rats
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