Abstract
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
Highlights
Vitamin D (25-hydroxyvitamin D: 25(OH) D) deficiency is a worldwide public health problem, affecting several population groups in various parts of the world[1]
Publications were excluded from this study if they met one or more of the following criteria: the publication was not available as full text, the publication was not in English, the study was based on animal or in vitro tests, the study did not analyze serum concentrations of 25(OH) D, the intervention was based only on food enrichment with vitamin D3, and studies that included children, adolescents, and pregnant women
The studies analyzed originated in different countries and different continents (South America, Australia, and Asia), were published in the last 3 years, and included genotyping of vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) (BsmI and FokI) and included both sexes
Summary
Vitamin D (25-hydroxyvitamin D: 25(OH) D) deficiency is a worldwide public health problem, affecting several population groups in various parts of the world[1]. It is considered a significant etiological factor in the pathogenesis of clinical conditions related to bone metabolism and chronic diseases such as obesity, type 2 diabetes mellitus, cardiovascular and autoimmune diseases, and some types. The VDR gene is located in chromosomal region 12q12.14 and is composed of eight exons coding for proteins (exons 2–9) and of six nontranslated, alternately spliced exons[9]. More than 25 genetic variants of VDR are possible, among which those caused by single-nucleotide polymorphisms (SNPs) may have significant consequences for health[10]
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