Effect of Vitamin D Therapy on Adiponectin level among type 2 Diabetes mellitus patients

Abstract

The aim of this study was to investigate the effect of weekly dose of 50.000IU vitamin D for 8 weeks on serum adiponectin level in diabetic patients who have vitamin D deficiency. The study has been included 80 female and male patients with type 2 diabetes mellitus who have vitamin D deficiency were ages range from 25 to 70 years old. The patients have been prepared to have fasting serum adiponectin and vitamin D level tests. After 8 weeks of treatment with vitamin D as an add-on to the conventional anti-diabetic drugs taken up by the patients, there was a highly significant improvement in vitamin D and serum adiponectin level. The mean ±Std. of vitamin D at the base line was 14.76 ±6.02 ng/ml and after 8 weeks' treatment was 42.865 ±12.012 ng/ml. For adiponectin level, the mean ±Std. at the base line and after 8weeks treatment with vitamin D was 7.316 ±1.563 ng/ml, 9.705 ±3.269 ng/ml respectively. As a conclusion, vitamin D level corrected and became in sufficient values after treatment with 50.000IU vitamin D for 8 weeks. Also there is a highly significant improvement in serum adiponectin level after 8 weeks of vitamin D treatment.