Abstract
AM Hibbs, K Ross, LA Kerns JAMA. 2018;319(20):2086–2094 To assess the effectiveness of 2 vitamin D dosing strategies in preventing recurrent wheezing in African American infants who are prematurely born. The study population consisted of 300 African American infants born between 28 and 36 weeks’ gestation (mean gestational age: 33 weeks; median birth weight: 1.9 kg) at 4 sites in the United States over a 3-year period. The subjects were then managed for the first year of life for the development of parent-reported recurrent wheezing defined as ≥2 episodes of wheezing with or without an infection (primary outcome). This was a multicenter, double-blind randomized clinical trial. Patients and families were enrolled before discharge from the NICU or newborn nursery. There was no standardization of the feeding protocol (formula or breast milk) in enrolled subjects. …
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