Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus.

S Westra,M M Ter Wee,H J Van Wijland,Y H M Krul-Poel,F Pouwer,F Stam,P Lips,S Simsek

doi:10.1530/ec-16-0070

Abstract

ObjectiveIncreased levels of depressive symptoms, fatigue or pain (all dimensions of reduced health-related quality of life (HRQOL)) are common in people with type 2 diabetes mellitus (DM). Earlier studies have reported associations between low vitamin D status and fatigue and depressive symptoms. The aim of the present study was to examine the effects of vitamin D supplementation on dimensions of HRQOL in people with type 2 DM.DesignRandomised, double-blind, placebo-controlled trial.MethodsThe effect of monthly cholecalciferol 50,000 IU vs placebo on HRQOL was assessed in 275 adults with type 2 DM derived from general practices. HRQOL at baseline and after six months using the Short Form 36 Health Survey (SF-36) was collected. Linear regression analyses were used to compare the change in HRQOL over time between the vitamin D and placebo group.Results187/275 (68%) completed baseline and follow-up SF-36 and were included in the analysis. Median serum 25-hydroxyvitamin D almost doubled in the intervention group compared to that in the placebo group (58.5–106.0 nmol/L vs 60.0–61.5 nmol/L, respectively). A small significant difference (adjusted B: −8.90; 95% CI: −17.16 to −0.65) between both groups was seen concerning the SF-36 domain role limitations due to physical problems in disadvantage of the vitamin D group.ConclusionsSix months of vitamin D supplementation did not improve HRQOL in non-vitamin D-deficient people with type 2 DM managed on oral antidiabetic therapy.

Highlights

With a total number of 415 million people in 2015, expecting to increase to a number of 642 million people in 2040, diabetes mellitus (DM) is a growing worldwide epidemic
A total number of 787 people were screened for eligibility of which 300 persons were recruited and 275 persons were randomised to either vitamin D supplementation (n = 136) or placebo (n = 139) (Fig. 1). 487 (62%) people were excluded from the study because they did not meet the inclusion criteria (75%, mostly because they used insulin) or refused to participate (25%)
The present study revealed that vitamin D supplementation did not affect health-related quality of life (HRQOL) (Fig. 2 and Table 2) in people with type 2 DM

Summary

Introduction

With a total number of 415 million people in 2015, expecting to increase to a number of 642 million people in 2040, diabetes mellitus (DM) is a growing worldwide epidemic. It is common knowledge that people with DM are at increased risk for microvascular and macrovascular complications, including neuropathy, nephropathy, retinopathy, peripheral artery disease and cardiovascular disease [1]. Depressive symptoms and fatigue in people with diabetes are related to an increased risk of developing diabetesspecific complications [2, 3]. People with depressive symptoms and diabetes had an almost 50% increased all-cause mortality rate, probably due to nonoptimal self-care [2]

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Results

Conclusion