Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency

Yosef H Saeed Abdelkarim

doi:10.11648/j.ijo.20160201.11

Abstract

Introduction: Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses. The pathogenesis of chronic rhino sinusitis remains poorly defined. It was recently proposed that Vitamin D deficiency may explain some part of this pattern. The aim of study is to evaluate the effect of vitamin D supplement in patients diagnosed as chronic rhino sinusitis with vitamin D deficiency. Materials and Methods: Prospective study was performed on 57 patients diagnosed as chronic Rhinosinusitis and vitamin D deficiency. Patients received vitamin D3 tablet (1000 IU) daily for one month. Before and after drug intake all patients were asked to fill in a questionnaire in which they rated their overall symptoms. Results: (75.4%) of patients cured from smell disturbance, (22.8%) of patients cured from headache, (21.1%) cured from nasal obstruction and only 7% of patients cured from nasal discharge. (64%) of patients improve (not cured) from nasal obstruction symptoms, (63%) of patients not cure from nasal discharge. Conclusions: Vitamin D supplement shows significant improvement in symptoms of chronic Rhinosinusitis mainly smell disturbance, Vitamin D could be use as adjuvant treatment for Chronic Rhino sinusitis.

Highlights

Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses
Inclusion criteria include age more than 18 years old, patients met the diagnostic criteria for chronic Rhino sinusitis(nasal obstruction, nasal discharge, smell disturbance and headache/facial pain), and serum vitamin D deficiency (
The predominant infiltrative cell in chronic Rhinosinusitis is the eosinophil, both in the allergic and the nonallergic patient, an increase in the levels of interleukin-4 and interleukin-5 in the sinonasal tract promotes the continued migration and prolonged life span of eosinophils, degranulation of eosinophils releases several destructive enzymes that damage the epithelium, this disrupts the normal barrier function and the mucociliary activity of the mucosa, allowing bacteria and fungi to colonize the sinus cavities [12]. Besides their classic role as regulators of calcium and phosphor homeostasis, vitamin D has emerged as a large family of antiproliferative agents; these observations suggest the potential of active vitamin D and its different derivatives and analogues as a therapy for chronic inflammatory diseases, including chronic Rhinosinusitis [13]

Summary

Introduction

Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses. The pathogenesis of chronic rhino sinusitis remains poorly defined. The aim of study is to evaluate the effect of vitamin D supplement in patients diagnosed as chronic rhino sinusitis with vitamin D deficiency. Materials and Methods: Prospective study was performed on 57 patients diagnosed as chronic Rhinosinusitis and vitamin D deficiency. Conclusions: Vitamin D supplement shows significant improvement in symptoms of chronic Rhinosinusitis mainly smell disturbance, Vitamin D could be use as adjuvant treatment for Chronic Rhino sinusitis. Patients complain mainly of nasal obstruction, nasal discharge, headache and olfactory loss. Various theories on the etiology and pathogenesis of chronic rhino sinusitis, such as allergy, bacterial and fungal infections, and structural abnormalities, have been proposed, the pathogenesis remains poorly defined [5]. It was recently proposed that Vitamin D deficiency may explain some part of this pattern [6]

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Methods

Conclusion