Abstract
The administration of 100,000 to 200,000 U of calciferol to adult dogs daily for 5 weeks caused marked hypercalcemia and significant decreases in plasma concentrations of sodium, potassium, magnesium and chloride. Cellular concentrations of calcium were increased by 30 to 300 % in muscle, myocardium, pancreas and aorta and were unchanged in liver, brain and nerve. Bone uptake of 47Ca was increased by 45 %. The exchangeable body and tissue pools of calcium were increased by 100% but the fractional rate of exchange of tissue calcium was unaltered. The magnesium concentrations of liver, pancreas and bone were increased by 16 to 20 % by calciferol and the fractional rate of exchange of tissue magnesium with 28Mg was increased by 23 %. Calciferol administration had a minor effect on tissue concentrations of acidsoluble phosphorus. The sodium concentrations of 5 tissues and the chloride concentrations of 3 tissues were significantly decreased, whereas the potassium concentrations of 2 tissues were increased sig...
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