Abstract
IT is known that the cytoplasm content of the liver is determined by protein nutrition1, and recently vitamin B12 has been shown to promote amino-acid assimilation2. A decrease in liver basophile cells (attributable to ribonucleic acid) is observed in rats deficient in vitamin B123. The vitamin also protects against hepatic damage during carbon tetrachloride intoxication, which causes a considerable reduction in the ribonucleic acid content of the liver4. All these findings suggest that vitamin B12 may influence protein as well as nucleic acid metabolism in the liver. We have sought direct experimental evidence for this in studies based on the regeneration of the labile liver cytoplasmic proteins in the rat following a brief fast. The results of a typical experiment are presented here.
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