Abstract
Summary and ConclusionsThe administration of large amounts of folic acid inhibited the increase of the urinary coproporphyrin in rabbits given Rose Bengal and exposed to ultraviolet light. The administration of small amounts of vit. B12 had the same effect. The combination of folic acid and vit. B12 had no advantage over either substance given separately. The administration of nicotinamide in large amount produced a significant but only partial inhibition.In view of the fact that nicotinamide, folic acid, and vit. B12 are all intimately related to cellular metabolism, it seems highly likely that the marked increases of urinary coproporphyrin under these experimental conditions are likewise so related, but whether to the metabolism of the bone marrow, or some other system of cells is not clear. Further studies of these relationships are in progress.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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