Abstract
Background: Different non-medical therapies such as Non-nutritive sucking (NNS), oral sucrose with or without NNS (non-nutritive sucking), wrapping with thin blanket or cloth, kangaroo mother care (KMC), songs as well as multi-sensory stimulation are beneficial in pain reduction among neonates and infants. According to the gate control theory, vibrations applied sat a site on the body block the nociceptive signals via the A???? and C fibers reducing the pain perception. When used along with many other nonpharmacological methods, This technique has been shown to minimize discomfort in pain-inducing treatments such as Intravenous cannulation, vaccines, heel prick, etc. The primary purpose of this study is to analyze vibrational therapy effects on infants pain perception, thereby, providing evidence for a better pain management strategy in vaccination centers.
 Objective: To determine the efficacy of vibration therapy on pain perception by infants during vaccine administration.
 Material and Methods: Out of total 90 eligible healthy infants who come for routinely immunization will be given either vibrational therapy (interventional group) or breastfeeding(control therapy) after doing randomization in this randomized controlled trial. The baseline vitals include cardiac rate (HR), respiratory rate (RR), and oxygen (SpO2) will be recorded before, during, and after vaccination during this treatment. Similarly, we will report Visual analog scales (VAS), Neonatal Infant Pain Scale (NIPS), and Wong-Baker FACES Pain Rating Scale, Modified Behavioral Pain Scale (MBPS) after giving the vaccine to the infant.
 Results: After completion of the study we will come to know the effect of vibratory therapy on pain control. The pain intensity with the help of the NIPS score will get less in the vibratory group than in the control group. The level of distress by using the Color Analogue Scale, MBPS scale, and FLACC scale, during the vaccine-related procedure will get a lower score in the infants who has taken vibratory therapy than the control group.
 Conclusion: study will probably give us information about vibration therapy, which will be an effective method for managing the pain after vaccination in infants.
Highlights
An indispensable segment of the health care delivery system is the routine vaccination of infants
Vaccination is considered as a outpatient procedure by health care providers (HCPs), a considerable percentage of infants experience intense fear resulting in irregularity on the recommended vaccination schedule
The intensity of the pain will be lower than the control group using the Neonatal Infant Pain Scale (NIPS) score
Summary
An indispensable segment of the health care delivery system is the routine vaccination of infants. Recent studies support the fact that pain experienced by neonates/ infants may contribute to various psychological sequelae up to or beyond the school years Such sequelae could have physiological and behavioral effects in infants which could be direct, short-term, longterm effects [3,4]. The age of the infants , temperament and previous painful experience has been found to have an impact on pain perception while the gender and position of the infants have no such impact [5] Different nonmedical therapies such as (NNS), oral sucrose with or without NNS (non-nutritive sucking), wrapping infants, kangaroo mother care (KMC), songs as well as multi-sensory stimulation are beneficial in pain reduction among neonates and infants. Objective: To determine the efficacy of vibration therapy on pain perception by infants during vaccine administration.
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