Abstract
The effect of different vibration conditions on the segregation tendency of three ordered powder mixes was studied. Segregation of the powders was measured using a cylinder, composed of interlocking units for sampling purposes, mounted on a vibration rig. Ordered mixes containing either Emdex or recrystallized lactose carrier particles mixed with 0.5% fine-particle potassium chloride were stable, except for slight segregation that occurred under severe vibration conditions at frequencies below 50 Hz and accelerations above 22 m s-2. Powder mixes of Dipac with potassium chloride were unstable at most vibration conditions from 20 to 1000 Hz and 7.4 to 29.4 m s-2. The intensity of segregation in vibrated mixes of Dipac with potassium chloride was most marked at frequencies below 50 Hz and accelerations above 22 m s-2. These vibration conditions were found to occur in several commonly-used types of tableting presses. When vibration was prolonged, for periods of 30 to 60 min, there was increased segregation found in ordered mixes.
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