Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study

Abstract

understanding the determinants of health burden after a fracture in ageing populations is important. assess the effect of clinical vertebral and other osteoporotic fractures on function and the subsequent risk of hospitalisation. individuals from the prospective population-based cohort study Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were examined between 2002 and 2006 and followed up for 5.4 years. a total of 5,764 individuals, 57.7% women, born 1907-35, mean age 77. four groups with a verified fracture status were used; vertebral fractures, other osteoporotic fractures excluding vertebral, non-osteoporotic fractures and not-fractured were compared and analysed for the effect on mobility, strength, QoL, ADL, co-morbidity and hospitalisation. worst performance on functional tests was in the vertebral fracture group for women (P<0.0001) and the other osteoporotic fractures group for men (P<0.05). Both vertebral and other osteoporotic fractures, showed an increased risk of hospitalisation, HR=1.4 (95% CI: 1.3-1.7) and 1.2 (95% CI: 1.1-1.2) respectively (P<0.0001). Individuals with vertebral fractures had 50% (P<0.0001) longer hospitalisation than not-fractured and 33% (P<0.002) longer than the other osteoporotic fractures group. individuals with a history of clinical vertebral fracture seem to carry the greatest health burden compared with other fracture groups, emphasising the attention which should be given to those individuals.