Abstract
To elucidate the role of calcium as a second messenger in gastric acid secretion, the effect of the calcium antagonist verapamil was studied in healthy subjects. Verapamil had no inhibitory effect on acid and pepsin secretion, stimulated with histamine, 6.4 micrograms X kg-1h-1 (no. = 6); pentagastrin, 0.10 micrograms X kg-1h-1 (no. = 9); or modified sham feeding (no. = 7). The results do not exclude the possibility that influx of calcium through channels in the parietal cell membrane could be of importance in the stimulus-secretion coupling of acid secretion. The results suggest, however, that these channels are not blocked by verapamil.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
