Abstract
Rats with bilateral electrolytic lesions of the ventromedial hypothalamus were maintained at either 80% of their preoperative lean weights or 80% of their postoperative obese weights. Unlike sham-operated rats maintained at 80% of their weights, neither group of lesioned rats acquired schedule-induced polydipsia after 15 daily 1-h sessions on a free variable-interval 1-min food schedule with water continuously available. The results are consistent with previous findings of reduced drinking responses of ventromedially lesioned rats to a variety of conditions which increase drinking in normal rats.
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