Effect of Vasopeptidase Inhibition on Myocardial and Vascular Collagen in Stroke Prone Spontaneously Hypertensive Rats.

Abstract

34 Left ventricular remodeling in hypertension is associated with cardiac interstitial and perivascular collagen deposition. The vasopeptidase inhibitor omapatrilat improves left ventricular remodeling in experimental heart failure. We hypothesized that omapatrilat would induce a regression of ventricular and vascular fibrosis in hypertension. We therefore investigated the effect of vasopeptidase inhibition on collagen deposition in heart and aorta of stroke prone spontaneously hypertensive rats (SHRSP). Ten-week old SHRSP were treated orally for 10 weeks with omapatrilat (40mg/kg/d). Collagen fibers in heart and descending thoracic aorta were stained with Sirius red. Collagen density was defined as the ratio of the area stained by Sirius red to the area of the studied field. After 10 weeks, systolic blood pressure was significantly (P 3 μm/mm section, respectively, P